You starve yourself of food and then you become weak, tired, and then you lose calories and energy which is bad for your health. Milk thistle is one of the frequently researched plants in association with promoting liver detoxification.
It can be depleted by large amounts of toxins and/or drugs passing through the liver, as well as starvation or fasting. Phase II reactions may follow Phase I for some molecules or act directly on the toxin or metabolite. For efficient phase two detoxification, the liver cells require sulphur-containing amino acids such as taurine and cysteine.
Furthermore, VLCDs accompanying many cleanse protocols could significantly increase your risk of nutritional deficiencies. Of course, this risk may vary depending on the duration and degree of restriction of a particular cleanse . Several studies in people with type 2 diabetes noticed that a VLCD regimen significantly reduced fasting blood sugar levels . It should be noted that most of the VLCDs in these studies also incorporated total nutrition needs as part of the dietary strategy.